ATP11A Products

Description

ATP11A is a widely expressed integral membrane ATPase. ATP11A is probably phosphorylated in its intermediate state and likely drives the transport of ions such as calcium or other molecules across membranes. While the exact molecule ATP11A transports is unknown, increased expression of ATP11A mRNA has been observed in murine leukemia cells made resistant to anti-cancer drugs such as farnesyltransferase inhibitors (FTIs). Furthermore, overexpression of ATP11A provided protection against the FTI SCH66336 while knockdown of ATP11A via siRNA made cells more sensitive to this drug. Other reports suggest that elevated levels of ATP11A mRNA may also be a predictive marker of metastasis in colorectal cancer patients.

Bioinformatics

Uniprot	NP_115565 Human
Product By Gene ID	23250
Alternate Names	ATPase, class VI, type 11A

Research Areas for ATP11A

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication