ATG4D Products

Description

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. FUNCTION: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes.; ENZYME REGULATION: Inhibited by N-ethylmaleimide; SUBCELLULAR LOCATION: Cytoplasm;

Bioinformatics

Entrez	84971 Human 235040 Mouse
Uniprot	Q8BGV9 Mouse
Product By Gene ID	84971
Alternate Names	APG4 autophagy 4 homolog D (S. cerevisiae) APG4 autophagy 4 homolog D APG4D APG4-D ATG4 autophagy related 4 homolog D (S. cerevisiae) AUTL4 AUT-like 4 cysteine endopeptidase AUT-like 4, cysteine endopeptidase (S. cerevisiae) AUT-like 4, cysteine endopeptidase autophagin-4 Autophagy-related cysteine endopeptidase 4 Autophagy-related protein 4 homolog D cysteine protease ATG4D cysteine protease involved in autophagy EC 3.4.22 EC 3.4.22.-

Research Areas for ATG4D

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Autophagy

Related ATG4D Blog Posts

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ATG4D - A regulator of autophagy and apoptosis Autophagy is an essential cellular process whereby damaged proteins and organelles are degraded and recycled. Autophagy, while happening constantly at a basal level, is tightly regulated and can be further induced under cellular stress. One of the ...    Read more.

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