ATF3 Products

Description

Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. Multiple transcript variants encoding two different isoforms have been found for this gene. The longer isoform represses rather than activates transcription from promoters with ATF binding elements. The shorter isoform (deltaZip2) lacks the leucine zipper protein-dimerization motif and does not bind to DNA, and it stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes.

Bioinformatics

Entrez	467 Human
Uniprot	AAH06322 Human NM_001030287 Human NP_001035709 Human NP_001665 Human NP_001665.1 Human P18847 Human
Product By Gene ID	467
Alternate Names	activating transcription factor 3cAMP-dependent transcription factor ATF-3 ATF3deltaZip2 ATF3deltaZip2c ATF3deltaZip3 cyclic AMP-dependent transcription factor ATF-3

Research Areas for ATF3

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Cancer
Transcription Factors and Regulators

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