ASAP1 Products

Description

ASAP1 (also known as AMAP1, 130-kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein, PIP2-dependent ARF1 GAP,ADP-ribosylation factor-directed GTPase-activating protein 1, ARF GTPase-activating protein 1, Development and differentiation-enhancing factor 1, Differentiation-enhancing factor 1, DEF-1) is an Arf-directed GTPase activating protein that is a substrate for the kinases Src and FAK and has been implicated in the regulation of membrane traffic, focal adhesions and invadopodia/podosomes. Phosphorylation of ASAP1 at tyrosine 782 has been found to affect enzymatic and some biological activities, including the function of invadopodia. ASAP1 is expressed in many tissues but is most abundant in the testis, brain, lung and spleen. A heightened expression was seen in the adipose tissue from obese (ob) and diabetic (db) animals. Multiple transcript variants have been reported for this protein.

Bioinformatics

Entrez	13196 Mouse 314961 Rat 50807 Human
Uniprot	NM_018482 Human NP_060952 Human NP_060952.2 Human
Product By Gene ID	50807
Alternate Names	130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activatingprotein AMAP1 ARF GTPase-activating protein 1 arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 centaurin, beta 4 CENTB4 DDEF1ADP-ribosylation factor-directed GTPase-activating protein 1 development and differentiation enhancing factor 1 Development and differentiation-enhancing factor 1 Differentiation-enhancing factor 1 KIAA1249DEF-1 PAG2 PAP PIP2-dependent ARF1 GAP ZG14P

Research Areas for ASAP1

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Phospho-Specific