Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Description
ACER1 hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. It has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. It may have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids.
Bioinformatics
| Uniprot |
Human
|
| Product By Gene ID |
125981 |
| Alternate Names |
- Acylsphingosine deacylase 3
- Alkaline CDase 1
- alkaline ceramidase 1
- AlkCDase 1
- ALKCDase1
- ASAH3
- EC 3.5.1.23
- MGC138327
- MGC138329
- N-acylsphingosine amidohydrolase (alkaline ceramidase) 3
- N-acylsphingosine amidohydrolase 3
|
