Arylsulfatase G/ARSG Products

Description

Sulfatases, such as ARSG, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules. This gene, a novel arylsulfatase, has activity toward pseudosubstrates including p-nitrocatechol sulfate and 4-methylumbelliferyl sulfate. Activity is competitively inhibited by phosphate. The unprocessed protein is active as a 63-kDa monomer and demonstrates an acidic pH optimum as typically seen for lysosomal sulfatases. The protein accumulates within lysosomes and is also a glycoprotein that binds specifically to mannose 6-phosphate receptors. [provided by RefSeq]

Bioinformatics

Entrez	22901 Human
Uniprot	NP_055775.2 Human Q96EG1 Human
Product By Gene ID	22901
Alternate Names	arylsulfatase G EC 3.1.6 EC 3.1.6.- EC 3.1.6.4 KIAA1001ASG

Research Areas for Arylsulfatase G/ARSG

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Lipid and Metabolism