ARFGAP1 Products

Description

The protein encoded by this gene is a GTPase-activating protein (GAP) which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1 (ARF1). The encoded protein promotes hydrolysis of ARF1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]. Transcript Variant: This variant (2) contains an alternate in-frame exon and utilizes an alternate in-frame splice site compared to variant 1. The resulting isoform (b) has the same N- and C-termini but contains an extra segment and lacks another compared to isoform a. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Bioinformatics

Product By Gene ID	55738
Alternate Names	ADP-ribosylation factor 1 GTPase activating protein ADP-ribosylation factor 1 GTPase-activating protein ADP-ribosylation factor GTPase activating protein 1 ADP-ribosylation factor GTPase-activating protein 1 ARF GAP 1 ARF1 GAP ARF1-directed GTPase-activating protein ARF1GAP ARFGAP1 bA261N11.3 FLJ10767 GAP protein HRIHFB2281 MGC39924