APPBP1 Products

Description

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.

Bioinformatics

Entrez	8883 Human
Uniprot	AAH00480 Human
Product By Gene ID	8883
Alternate Names	A-116A10.1 amyloid beta precursor protein binding protein 1, 59kDa Amyloid beta precursor protein-binding protein 1, 59 kDa amyloid beta precursor protein-binding protein 1, 59kD APPBP1 APP-BP1 HPP1 NAE1 NEDD8 activating enzyme E1 subunit 1 NEDD8-activating enzyme E1 regulatory subunit NEDD8-activating enzyme E1 subunit protooncogene protein 1 Proto-oncogene protein 1 ula-1

Research Areas for APPBP1

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Apoptosis