APCDD1 Products

Description

Adenomatosis polyposis coli down-regulated 1 protein (APCDD1), also known as DRAPC1, is a negative regulator of the Wnt signaling pathway. APCDD1 acts to inhibit Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin interaction. APCDD-1 is most strongly expressed in pancreas, heart, prostate, ovary, lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. APCDD1 is expressed in both the epidermal and dermal compartments of the hair follicle, and in the dermal papilla, the matrix, and the hair shaft. Mutations in the APCDD1 gene cause hypotrichosis simplex (HTS), a rare form of non-syndromic hereditary hypotrichosis characterized by progressive hairloss in early childhood. The APCDD1 protein has also been found overexpressed in colorectal carcinogenesis and is deregulated in CTNNB1-mutated Wilms tumors.

APCDD1 antibodies may be useful for hair loss studies and research on certian cancers.

Bioinformatics

Entrez	147495 Human 494504 Mouse
Uniprot	NM_153000 Human NM_153000 Human NP_694545 Human NP_694545 Human NP_694545.1 Human NP_694545.1 Human Q8J025 Human Q8J025 Human
Product By Gene ID	147495
Alternate Names	Adenomatosis polyposis coli down-regulated 1 protein adenomatosis polyposis coli down-regulated 1 B7323 DRAPC1 protein APCDD1

Research Areas for APCDD1

Find related products by research area and learn more about each of the different research areas below.

Cancer