Hu, Mu, Ch, ReApplications:
Applications: Flow, CyTOF-ready
Host: Rabbit Monoclonal
WB, ICC/IF, IHC, IHC-FrHost:
Adenomatosis polyposis coli down-regulated 1 protein (APCDD1), also known as DRAPC1, is a negative regulator of the Wnt signaling pathway. APCDD1 acts to inhibit Wnt signaling in a cell-autonomous manner and functions upstream of beta-catenin interaction.
APCDD-1 is most strongly expressed in pancreas, heart, prostate, ovary, lung, liver, kidney, spleen, thymus, colon and peripheral lymphocytes. APCDD1 is expressed in both the epidermal and dermal compartments of the hair follicle, and in the dermal papilla, the matrix, and the hair shaft. Mutations in the APCDD1 gene cause hypotrichosis simplex (HTS), a rare form of non-syndromic hereditary hypotrichosis characterized by progressive hairloss in early childhood. The APCDD1 protein has also been found overexpressed in colorectal carcinogenesis and is deregulated in CTNNB1-mutated Wilms tumors.
APCDD1 antibodies may be useful for hair loss studies and research on certian cancers.
Research Areas for APCDD1
Find related products by research area and learn more about each of the different research areas below.Cancer
PTMs for APCDD1
Learn more about PTMs related to APCDD1.Methylation
Bioinformatics Tool for APCDD1
Discover related pathways, diseases and genes to APCDD1. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.