ALS2CR2 Products

Description

ALS2CR2 encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. [provided by RefSeq]

Bioinformatics

Entrez	227154 Mouse 501146 Rat 55437 Human
Uniprot	AAF71042 Human AAH08302 Human NM_018571 Human NP_061041 Human NP_061041.2 Human Q9C0K7 Human
Product By Gene ID	55437
Alternate Names	ALS2CR2candidate 2 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein CALS-21MGC102916 ILP-interacting protein ILPIPSTRAD beta Pseudokinase ALS2CR2 STE20-related kinase adaptor beta

Diseases related to ALS2CR2

Discover more about diseases related to ALS2CR2.

Sclerosis
Primary Lateral Sclerosis
Neurodegenerative Disorders
Nerve Degeneration
Amyotrophic Lateral Sclerosis

Research Areas for ALS2CR2

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Apoptosis
Protein Kinase
Signal Transduction

Bioinformatics Tool for ALS2CR2

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