Species: Hu, Mu, Rt, Bv, Ca, Eq, Pm, Ch, Ma-Op, Ze
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Species: Hu, Bv, Ca
Applications: WB, ICC/IF, IHC, IHC-P, PEP-ELISA
Host: Goat Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, PA, AP, KA
Species: Hu
Applications: WB, ELISA, PA, AP
Species: Hu
Applications: WB, ELISA, PA, AP
Description
ALS2CR2 encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. [provided by RefSeq]
Bioinformatics
Entrez |
Mouse Rat Human |
Uniprot |
Human Human Human Human Human Human |
Product By Gene ID |
55437 |
Alternate Names |
- ALS2CR2candidate 2
- Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein
- CALS-21MGC102916
- ILP-interacting protein
- ILPIPSTRAD beta
- Pseudokinase ALS2CR2
- STE20-related kinase adaptor beta
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Bioinformatics Tool for ALS2CR2
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