alpha Tubulin 4a Products

Description

Microtubules are involved in a wide variety of cellular activities ranging from mitosis and transport events to cell movement and the maintainance of cell shape. Tubulin itself is a globular protein which consists of two polypeptides (alpha and beta tubulin). Alpha and beta tubulin dimers are assembled to 13 protofilaments that form a microtubule of 22 nm diameter. Tyrosine ligase ads a C-terminal tyrosin to monomeric alpha tubulin. Assembled microtubules can again be detyrosinated by a cytoskeleton associated carboxypeptidase. Detyrosinated alpha tubulin is referred to as Glu-tubulin. Another post-translational modification of detyrosinated alpha tubulin is C-terminal polyglutamylation which is characteristic for microtubules in neuronal cells and the mitotic spindle. Alpha tubulin is not suitable as loading control in adipose tissue as expression of tubulin in adipose tissue is very low ( Spiegelman and Farmer, Cell, 1982, 29(1):53-60) in cells undergoing adipose differentiation actin synthesis decreases by 90%. Excellent as a protein loading control antibody.

Bioinformatics

Product By Gene ID	7277
Alternate Names	alpha 1 (testis specific) alpha Tubulin 4a Alpha-tubulin 1 FLJ30169 H2-ALPHA Testis-specific alpha-tubulin TUBA1 TUBA4A Tubulin alpha-1 chain tubulin alpha-4A chain Tubulin H2-alpha tubulin, alpha 1 tubulin, alpha 4a

Research Areas for alpha Tubulin 4a

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Cell Biology
Cellular Markers
Stem Cell Markers

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Tubulin alpha 4A - A ubiquitous tubulin isoform linked to ALS and infertility Microtubules are a main component of the cytoskeleton and play essential roles in a variety of cellular processes. These highly dynamic tubular structures are assembled from alpha- and beta-tubulin dimers to form a complex structural network of mic...    Read more.

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