alpha-Internexin Products

Description

Alpha-internexin is a Class IV intermediate filament, related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H. It is expressed only in neurons and in large amounts early in neuronal development, but is down-regulated in many neurons as development procedes. However, many classes of mature neurons contain alpha-internexin in addition to NF-L, NF-M and NF-H, and some mature neurons only express the alpha-internexin subunit of neurofilament.

The very early developmental expression of alpha-internexin suggests that its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cell committed to the neuronal lineage. Therefore, alpha-internexin antibodies serve as unique probes to study and classify neuronal types and follow their processes in tissue sections and culture.

Bioinformatics

Entrez	9118 Human 226180 Mouse 24503 Rat
Uniprot	NP_116116 Human NP_116116.1 Human P23565 Rat
Product By Gene ID	9118
Alternate Names	TXBP-1 Neurofilament 5 MGC12702 Neurofilament-66 FLJ57501 Alpha-Inx FLJ18662 neurofilament-66, tax-binding protein NEF5 neurofilament 5 (66kD) 66 kDa neurofilament protein NF-66alpha-internexin alpha-Inx internexin neuronal intermediate filament protein, alpha

Diseases related to alpha-Internexin

Discover more about diseases related to alpha-Internexin.

Neoplasms
Pain
Malignant Neoplasms
Plant Diseases
Oligodendroglioma
Glioma
Hiv Infections
Obesity
Malnutrition
Brain Neoplasms
Astrocytoma
Infective Disorder
Dermatitis, Phototoxic
Systemic Infection
Glioblastoma
Myocardial Infarction
Ischemia
Cardiac Arrhythmia
Influenza

Pathways for alpha-Internexin

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Systemic Acquired Resistance
Disease Resistance
Pathogenesis
Cell Death
Regeneration
Localization
Membrane Fusion
Excretion
Secretion
Cold Acclimation
Transport
Complement Activation
Phagocytosis
Fibrinolysis
Mitosis
Methylation
Transposition
Mitochondrial Depolarization
Cognition
Interphase

Research Areas for alpha-Internexin

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Cancer
Cytoskeleton Markers
Neuronal Cell Markers
Neuroscience

PTMs for alpha-Internexin

Learn more about PTMs related to alpha-Internexin.

Cleavage
Phosphorylation
Glycosylation
Methylation
Oxidation
Acetylation
Iodination

Bioinformatics Tool for alpha-Internexin

Discover related pathways, diseases and genes to alpha-Internexin. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.