alpha 1 Mannosidase 1A Products

Antibodies
alpha 1 Mannosidase 1A Antibo ...
alpha 1 Mannosidase 1A Antibody
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
alpha 1 Mannosidase 1A Antibo ...
alpha 1 Mannosidase 1A Antibody
NBP2-37938
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
alpha 1 Mannosidase 1A Antibo ...
alpha 1 Mannosidase 1A Antibody
NBP2-38030
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
alpha 1 Mannosidase 1A Overex ...
alpha 1 Mannosidase 1A Overexpress...
H00004121-T01
Species: Hu
Applications: WB
Proteins
alpha 1 Mannosidase 1A Recomb ...
alpha 1 Mannosidase 1A Recombinant...
NBP2-37938PEP
Species: Hu
Applications: AC
Recombinant Human alpha 1 Man ...
Recombinant Human alpha 1 Mannosid...
H00004121-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human alpha 1 Man ...
Recombinant Human alpha 1 Mannosid...
H00004121-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
alpha 1 Mannosidase 1A RNAi
alpha 1 Mannosidase 1A RNAi
H00004121-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

a1,2-Mannosidase IA is a Type II transmembrane Golgi-resident enzyme that belongs to class I a1,2-Mannosidases (glycosylhydrolase family 47). a1,2-Mannosidases plays an essential role in the maturation of N-glycans to hybrid and complex oligosaccharides in mammalian cells. Class I a1,2- Mannosidases are conserved through evolution. They can be classified into three subgroups according to their enzymatic activities. The first subgroup includes yeast and human endoplasmic reticulum (ER) a1,2-Mannosidases that primarily trim Man9GlcNAc2 to Man8GlcNAc2 isomer B. The second subgroup includes mammalian Golgi a1,2-Mannosidases IA, IB, and IC that trim Man9GlcNAc2 to Man5GlcNAc2 through Man8GlcNAc2 isomer A and C. These Golgi mannosidases display different tissue- and cell-specific expression, subcellular localization, and substrate specificity. The third subgroup includes yeast and mammalian proteins that do not hydrolyze Man9GlcNAc2. Proteins from subgroup 1 and 3 have been implicated in ER quality control and in proteasomal degradation of misfolded glycoproteins. It was also suggested that Golgi mannosidases from the second subgroup may play a role in the ERAD (endoplasmic reticulum-associated degradation) of defective glycoproteins 1-5. Although a1,2-Mannosidase IA is predominantly detected in the juxtanuclear Golgi region by indirect immunofluorescence, significant cell type and speciesdependent variation in localization was reported. The pig liver enzyme has been localized to the ER and transitional vesicles between ER and Golgi, but is not found within the Golgi stacks of porcine hepatocytes.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 4121
Alternate Names
  • HUMM9
  • EC 3.2.1
  • HUMM3
  • Mannosidase alpha class 1A member 1
  • EC 3.2.1.113
  • Man(9)-alpha-mannosidase
  • Man9-mannosidase
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase IA
  • Processing alpha-1,2-mannosidase IA
  • man(9)-alpha-mannosidase
  • Alpha-1,2-mannosidase IA
  • MAN9
  • mannosidase, alpha, class 1A, member 1

Diseases related to alpha 1 Mannosidase 1A

Discover more about diseases related to alpha 1 Mannosidase 1A.

Childhood Leukemia
Malignant Neoplasms
Neoplasms
Leukemia
Malignant Neoplasm Of Breast
Mammary Neoplasms
L1 Acute Lymphoblastic Leukemia
Acute Lymphocytic Leukemia

Research Areas for alpha 1 Mannosidase 1A

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Golgi Apparatus Markers

Bioinformatics Tool for alpha 1 Mannosidase 1A

Discover related pathways, diseases and genes to alpha 1 Mannosidase 1A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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