Aldo-keto Reductase 1C1/AKR1C1 Products

Description

AKR1C1 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Bioinformatics

Entrez	1645 Human
Uniprot	AAH20216 Human NP_001344 Human NP_001344.2 Human Q04828 Human
Product By Gene ID	1645
Alternate Names	20 alpha-hydroxysteroid dehydrogenase 20-ALPHA-HSD 20-alpha-HSD 20-alpha-hydroxysteroid dehydrogenase aldo-keto reductase family 1 member C1 aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha(3-alpha)-hydroxysteroid dehydrogenase) C9 Chlordecone reductase homolog HAKRC DD1/DD2 DD1MGC8954 DDHH-37 dihydrodiol dehydrogenase 1 Dihydrodiol dehydrogenase 1/2 dihydrodiol dehydrogenase isoform DD1 EC 1.1.1 EC 1.1.1.- EC 1.1.1.112 EC 1.1.1.149,2-ALPHA-HSD EC 1.3.1.20 HAKRCDDH1aldo-keto reductase C HBAB hepatic dihydrodiol dehydrogenase High-affinity hepatic bile acid-binding protein Indanol dehydrogenase MBAB Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase type II 3-alpha-hydroxysteroid dehydrogenase