AKR1B1 Products

Antibodies
AKR1B1 Antibody
AKR1B1 Antibody
NBP1-89146
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
AKR1B1 Antibody
AKR1B1 Antibody
NBP1-53144
Species: Hu
Applications: WB, IHC
Host: Rabbit Polyclonal
AKR1B1 Antibody (2D12)
AKR1B1 Antibody (2D12)
H00000231-M03
Species: Hu
Applications: WB, ELISA, IHC-P
Host: Mouse Monoclonal
Lysates
AKR1B1 Overexpression Lysate ...
AKR1B1 Overexpression Lysate (Dena...
H00000231-T01
Species: Hu
Applications: WB
AKR1B1 Overexpression Lysate ...
AKR1B1 Overexpression Lysate (Dena...
H00000231-T02
Species: Hu
Applications: WB
Proteins
Recombinant Human AKR1B1 Prot ...
Recombinant Human AKR1B1 Protein
NBC1-22925
Species: Hu
Applications: Func, PAGE
Recombinant Mouse AKR1B1 Prot ...
Recombinant Mouse AKR1B1 Protein
NBP2-51989
Species: Mu
Applications: Func, PAGE
Recombinant Human AKR1B1 Prot ...
Recombinant Human AKR1B1 Protein
H00000231-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
AKR1B1 RNAi
AKR1B1 RNAi
H00000231-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Aldose reductase (also designated AKR1B1, ALDR1, ALR2 or AR) is member of the monomeric NADPH-dependent aldoketoreductase family. Aldose reductase, which has a molecular mass of 36 kDa, catalyzes the reduction of various aldehydes and has been implicated in the development of diabetic complications by catalyzing the reduction of the aldehyde form of glucose, to the corresponding sugar alcohol, sorbitol. This pathway plays a minor role in glucose metabolism in most tissues, however in diabetic hyperglycemia, cells undergoing insulin-independent uptake of glucose accumulate significant quantities of sorbitol. The resulting hyperosmotic stress to cells may be a cause of diabetic complications such as neuropathy, retinopathy, and cataracts. Aldose reductase is very similar to human aldehyde reductase, bovine prostaglandin F synthase and to the European common frog protein, rho-crystallin.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Product By Gene ID 231
Alternate Names
  • MGC1804
  • EC 1.1.1
  • ALR2
  • Aldehyde reductase
  • ADR
  • low Km aldose reductase
  • EC 1.1.1.21
  • Lii5-2 CTCL tumor antigen
  • Aldo-keto reductase family 1 member B1
  • ALDR1aldose reductase
  • ARaldehyde reductase 1
  • aldo-keto reductase family 1, member B1 (aldose reductase)

Research Areas for AKR1B1

Find related products by research area and learn more about each of the different research areas below.

Stem Cell Markers

Bioinformatics Tool for AKR1B1

Discover related pathways, diseases and genes to AKR1B1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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