AKAP1 Products

Description

The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates. Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell. To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins. This family of proteins has been designated A-kinase anchoring proteins (AKAP). Members of this family, including MAP2 (microtubule-associated protein 2), neuronally expressed AKAP 79 and AKAP 150, and the DNA binding AKAP 95, display differential tissue specificity and localization. Evidence suggests that AKAP 79 and AKAP 150 are both capable of anchoring PKA to postsynaptic densities (PSD), which are a network of proteins located on the internal surfaces of excitatory synapses.

Bioinformatics

Entrez	8165 Human
Product By Gene ID	8165
Alternate Names	A kinase (PRKA) anchor protein 1 a kinase anchor protein 1, mitochondrial AKAP121 AKAP149AKAP 149 AKAP84 A-kinase anchor protein 1, mitochondrial A-kinase anchor protein 149 kDa A-kinase anchor protein, 149kD D-AKAP1 D-AKAP-1 Dual specificity A-kinase-anchoring protein 1 dual-specificity A-kinase anchoring protein 1 MGC1807 PRKA1 protein kinase A anchoring protein 1 protein kinase A1 Protein kinase A-anchoring protein 1 protein kinase anchoring protein 1 S-AKAP84 SAKAP84AKAP Spermatid A-kinase anchor protein 84