ADAMTS4 Products

Description

ADAMTS4, also known as aggrecanase-1, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan and the brain extracellular matrix proteoglycan brevican. The ADAMTS4 protein contains a signal sequence, a propeptide domain, a catalytic domain, a disintegrin-like motif, and a C-terminal domain with a thrombospondin (TSP) type 1 motif. ADAMTS4 has been implicated in inflammatory joint diseases, and it also may be a factor in the progression of glioma and Alzheimer's disease. ADAMTS4 expression has been documented in normal human brain, cartilage, heart, lung, placenta, muscle, and synovium. ESTs have been isolated from human tissue libraries, including normal brain, lung, pancreas, and skeletal muscle and cancerous breast.

Bioinformatics

Entrez	9507 Human
Uniprot	AAH63293 Human NP_005090 Human O75173 Human
Product By Gene ID	9507
Alternate Names	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 ADAM-TS 4 ADAMTS-2 ADAM-TS4 ADAMTS-4 ADMP-1EC 3.4.24.82 Aggrecanase-1 aggrecanase-1 EC 3.4.24 KIAA0688A disintegrin and metalloproteinase with thrombospondin motifs 4

Diseases related to ADAMTS4

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Degenerative Polyarthritis
Arthritis
Neoplasms
Abnormal Degeneration
Chondrosarcoma
Inflammation
Tumor Angiogenesis
Malignant Neoplasms
Rheumatoid Arthritis
Malignant Paraganglionic Neoplasm
Infarction
Atherosclerosis
Glioma
Fracture
Myocardial Infarction
Arthropathy
Dental Plaque
Cell Invasion
Neoplasm Metastasis
Neoplasm Invasiveness

Pathways for ADAMTS4

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Proteolysis
Angiogenesis
Pathogenesis
Localization
Cell Death
Cell Migration
Reverse Transcription
Cell Proliferation
Ovulation
Rna Interference
Cell Adhesion
Protein Catabolic Process
Aging
Chondrocyte Hypertrophy
Inflammatory Response
Tooth Eruption
Cell Differentiation
Wound Healing
Catabolic Process
Bone Mineralization

Research Areas for ADAMTS4

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Cancer
GPCR
Neuroscience
Vision

PTMs for ADAMTS4

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Cleavage
Phosphorylation
Nitration
Sulphation
Methylation

Bioinformatics Tool for ADAMTS4

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