ADAMTS4 Products

Antibodies
ADAMTS4 Antibody (416610) [Un ...
ADAMTS4 Antibody (416610) [Unconju...
MAB4307
Species: Hu
Applications: WB, IP, B/N, ICC/IF
Host: Mouse Monoclonal
Formulation Catalog # Availability Price  
ADAMTS4 Antibody
ADAMTS4 Antibody
NBP1-54369
Species: Hu, Mu, Rt, Bv, Ca, Eq, Gp, Rb
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
ADAMTS4 Antibody
ADAMTS4 Antibody
NBP3-06665
Species: Hu, Mu, Po, Bt, Ca, Eq, Pm, Pm-Or, Pm
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
ELISA Kits
Human ADAMTS4 DuoSet ELISA, 5 ...
Human ADAMTS4 DuoSet ELISA, 5 Plate
DY4307-05
Species: Hu
Applications: ELISA
Human ADAMTS4 ELISA Kit (Chem ...
Human ADAMTS4 ELISA Kit (Chemilumi...
NBP2-66443
Species: Hu
Applications: ELISA
Kits
ADAMTS4 Activity Assay Kit (C ...
ADAMTS4 Activity Assay Kit (Colori...
KA1497
Species: Hu, Rt
Applications: Func
ADAMTS4 Activity Assay Kit (C ...
ADAMTS4 Activity Assay Kit (Colori...
KA1498
Applications: Func
Lysates
ADAMTS4 Overexpression Lysate ...
ADAMTS4 Overexpression Lysate
NBP2-07792
Species: Hu
Applications: WB
Proteins
Recombinant Human ADAMTS4 Pro ...
Recombinant Human ADAMTS4 Protein, CF
4307-AD
Species: Hu
Applications: Enzyme Activity
Formulation Catalog # Availability Price  
ADAMTS4 Recombinant Protein A ...
ADAMTS4 Recombinant Protein Antigen
NBP2-57839PEP
Species: Hu
Applications: AC
ADAMTS4 Recombinant Protein A ...
ADAMTS4 Recombinant Protein Antigen
NBP2-56239PEP
Species: Hu
Applications: AC

Description

ADAMTS4, also known as aggrecanase-1, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan and the brain extracellular matrix proteoglycan brevican. The ADAMTS4 protein contains a signal sequence, a propeptide domain, a catalytic domain, a disintegrin-like motif, and a C-terminal domain with a thrombospondin (TSP) type 1 motif. ADAMTS4 has been implicated in inflammatory joint diseases, and it also may be a factor in the progression of glioma and Alzheimer's disease. ADAMTS4 expression has been documented in normal human brain, cartilage, heart, lung, placenta, muscle, and synovium. ESTs have been isolated from human tissue libraries, including normal brain, lung, pancreas, and skeletal muscle and cancerous breast.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 9507
Alternate Names
  • ADAMTS-4
  • EC 3.4.24
  • ADAM-TS4
  • Aggrecanase-1
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 4
  • aggrecanase-1
  • ADAMTS-2
  • KIAA0688A disintegrin and metalloproteinase with thrombospondin motifs 4
  • ADMP-1EC 3.4.24.82
  • ADAM-TS 4
  • ADAM metallopeptidase with thrombospondin type 1 motif, 4

Research Areas for ADAMTS4

Find related products by research area and learn more about each of the different research areas below.

Cancer
GPCR
Neuroscience
Vision

PTMs for ADAMTS4

Learn more about PTMs related to ADAMTS4.

Cleavage
Phosphorylation
Nitration
Sulphation
Methylation

Bioinformatics Tool for ADAMTS4

Discover related pathways, diseases and genes to ADAMTS4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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