ADAMTS4 Products

Description

ADAMTS4, also known as aggrecanase-1, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan and the brain extracellular matrix proteoglycan brevican. The ADAMTS4 protein contains a signal sequence, a propeptide domain, a catalytic domain, a disintegrin-like motif, and a C-terminal domain with a thrombospondin (TSP) type 1 motif. ADAMTS4 has been implicated in inflammatory joint diseases, and it also may be a factor in the progression of glioma and Alzheimer's disease. ADAMTS4 expression has been documented in normal human brain, cartilage, heart, lung, placenta, muscle, and synovium. ESTs have been isolated from human tissue libraries, including normal brain, lung, pancreas, and skeletal muscle and cancerous breast.

Bioinformatics

Entrez	9507 Human
Uniprot	AAH63293 Human NP_005090 Human O75173 Human
Product By Gene ID	9507
Alternate Names	a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 4 ADAM metallopeptidase with thrombospondin type 1 motif, 4 ADAM-TS 4 ADAMTS-2 ADAM-TS4 ADAMTS-4 ADMP-1EC 3.4.24.82 Aggrecanase-1 aggrecanase-1 EC 3.4.24 KIAA0688A disintegrin and metalloproteinase with thrombospondin motifs 4

Research Areas for ADAMTS4

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Cancer
GPCR
Neuroscience
Vision