ADAMTS13 Products

Antibodies
ADAMTS13 Antibody (442323) [U ...
ADAMTS13 Antibody (442323) [Unconj...
MAB4245
Species: Hu
Applications: WB, IP, CyTOF-ready, ICFlow
Host: Mouse Monoclonal
ADAMTS13 Antibody
ADAMTS13 Antibody
NB100-584
Species: Hu, Mk, Pm
Applications: WB
Host: Rabbit Polyclonal
ADAMTS13 Antibody
ADAMTS13 Antibody
NBP2-14265
Species: Hu
Applications: WB, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
ADAMTS13 Overexpression Lysat ...
ADAMTS13 Overexpression Lysate (Na...
NBP2-05570
Applications: WB
Proteins
Recombinant Human ADAMTS13 Pr ...
Recombinant Human ADAMTS13 Protein
H00011093-Q01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human ADAMTS13 Pr ...
Recombinant Human ADAMTS13 Protein
H00011093-P01
Species: Hu
Applications: WB, ELISA, PA
ADAMTS13 Recombinant Protein ...
ADAMTS13 Recombinant Protein Antigen
NBP2-14265PEP
Species: Hu
Applications: AC
RNAi
ADAMTS13 RNAi
ADAMTS13 RNAi
H00011093-R03
Species: Hu
Applications: RNAi, RNAi SP
ADAMTS13 RNAi
ADAMTS13 RNAi
H00011093-R02
Species: Hu
Applications: RNAi, RNAi SP
ADAMTS13 RNAi
ADAMTS13 RNAi
H00011093-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

ADAMTS13 was first identified by its ability to cleave the ultra large aggregates of vWF into smaller forms in the serum. A thrombocytopenic disorder called thrombic thrombocytopenic purpura (TTR) was shown to be due to a deficiency in the cleavage of von Willebrands factor, and ADAMTS13 was identified as the enzyme responsible. ADAMTS13 cleaves the Tyr1605 to Met1606 bond in the A2 domain of vWF, a process stimulated by shear stress in the circulation and by binding to either platelet glycoprotein IBa or to heparin. The cleaved vWF leads to decreased platelet adhesion. An idiopathic form of TTR is found in patients with auto antibodies to ADAMTS13. The full length ADAMTS-1 sequence codes for a 1,427 amino acid protein, with a predicted mass of 153.6 kDa, but glycosylation and the abundance of cysteine residues gives ADAMTS-13 an apparent molecular weight of about 190 kDa on reduced SDS PAGE gels. The variants reported include 1,371, 1,340 and 344 amino acids, with predicted mass of 130.3, 144.5 and 36.7 kDa respectively. Many bands of varying sizes can be seen on Western blots, between 110-190 kDa, perhaps indicating differentially processed ADAMTS-13.

Bioinformatics

Entrez Human
Uniprot Human
Human
Human
Product By Gene ID 11093
Alternate Names
  • ADAM-TS13
  • EC 3.4.24.82
  • a disintegrin-like and metalloprotease (reprolysin type) with thrombospondintype 1 motif, 13
  • EC 3.4.24.14
  • MGC118900
  • EC 3.4.24.87
  • MGC118899
  • A disintegrin and metalloproteinase with thrombospondin motifs 13
  • FLJ42993
  • vWF-cleaving protease
  • DKFZp434C2322
  • VWFCPvon Willebrand factor-cleaving protease
  • TTPADAM-TS 13
  • vWF-CPC9orf8
  • ADAMTS-13
  • ADAM metallopeptidase with thrombospondin type 1 motif, 13

Research Areas for ADAMTS13

Find related products by research area and learn more about each of the different research areas below.

Cancer
Signal Transduction

PTMs for ADAMTS13

Learn more about PTMs related to ADAMTS13.

Cleavage
Oxidation
Reduction
Glycosylation
Phosphorylation
Deglycosylation
Ubiquitination

Bioinformatics Tool for ADAMTS13

Discover related pathways, diseases and genes to ADAMTS13. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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