Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Rt
Applications: WB, ELISA, IP
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, Flow
Host: Rabbit Monoclonal
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.
Bioinformatics
| Product By Gene ID |
48 |
| Alternate Names |
- aconitase 1, soluble
- Aconitase
- aconitate hydratase
- Citrate hydro-lyase
- cytoplasmic aconitate hydratase
- EC 4.2.1
- EC 4.2.1.3
- Ferritin repressor protein
- IREB1IREBP1
- IRE-BP 1
- IREBP
- Iron regulatory protein 1
- iron-responsive element binding protein 1
- Iron-responsive element-binding protein 1
- IRP1ACONS
|
