Aconitase 1 Products

Antibodies
Aconitase 1 Antibody
Aconitase 1 Antibody
NBP1-87677
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Aconitase 1 Antibody (2C1)
Aconitase 1 Antibody (2C1)
H00000048-M01
Species: Hu
Applications: WB, ELISA, IP
Host: Mouse Monoclonal
Aconitase 1 Antibody
Aconitase 1 Antibody
NBP1-87678
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Antibody Pairs
Aconitase 1 Antibody Pair
Aconitase 1 Antibody Pair
H00000048-PW1
Species: Hu
Applications: WB, IP
Aconitase 1 Antibody Pair
Aconitase 1 Antibody Pair
H00000048-PW2
Species: Hu
Applications: WB, IP
Kits
Aconitase 1 Assay Kit
Aconitase 1 Assay Kit
KA0876
Species: Hu, Mu, Rt, Ma
Applications: Func
Lysates
Aconitase 1 Overexpression Ly ...
Aconitase 1 Overexpression Lysate ...
H00000048-T01
Species: Hu
Applications: WB
Aconitase 1 Overexpression Ly ...
Aconitase 1 Overexpression Lysate ...
NBL1-07243
Applications: WB
Proteins
Aconitase 1 Recombinant Prote ...
Aconitase 1 Recombinant Protein An...
NBP1-87678PEP
Species: Hu
Applications: AC
Aconitase 1 Recombinant Prote ...
Aconitase 1 Recombinant Protein An...
NBP1-87677PEP
Species: Hu
Applications: AC
Aconitase 1 Recombinant Prote ...
Aconitase 1 Recombinant Protein
NBP1-50955
Applications: PAGE
RNAi
Aconitase 1 RNAi
Aconitase 1 RNAi
H00000048-R01
Species: Hu

Description

The insulin receptor substrate-1 (IRS-1), a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor. The association of 14-3-3 with IRS-1 increases significantly upon treatment with okadaic acid, a potent serine/ threonine phosphatase inhibitor. Therefore, the association of 14-3-3 protein may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Product By Gene ID 48
Alternate Names
  • EC 4.2.1
  • IRE-BP 1
  • Aconitase
  • Iron-responsive element-binding protein 1
  • iron-responsive element binding protein 1
  • Iron regulatory protein 1
  • cytoplasmic aconitate hydratase
  • Ferritin repressor protein
  • aconitate hydratase
  • Citrate hydro-lyase
  • IREBP
  • IREB1IREBP1
  • IRP1ACONS
  • EC 4.2.1.3
  • aconitase 1, soluble

PTMs for Aconitase 1

Learn more about PTMs related to Aconitase 1.

Phosphorylation
Oxidation
Glycosylation
Dephosphorylation

Bioinformatics Tool for Aconitase 1

Discover related pathways, diseases and genes to Aconitase 1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.