Species: Hu, Mu, Rt
Applications: WB, ELISA, Flow, ICC/IF, IHC
Host: Mouse Monoclonal
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, Simple Western
Host: Goat Polyclonal
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Description
The cbl oncogene was first identified as part of a transforming retrovirus which induces mouse pre-B and pro-B cell lymphomas. As an adaptor protein for receptor protein-tyrosine kinases, it positively regulates receptor protein-tyrosine kinase ubiquitination in a manner dependent upon its variant SH2 and RING finger domains. Ubiquitination of receptor protein-tyrosine kinases terminates signaling by marking active receptors for degradation.
Bioinformatics
| Entrez |
Human
|
| Uniprot |
Human
|
| Product By Gene ID |
867 |
| Alternate Names |
- Cas-Br-M (murine) ecotropic retroviral transforming sequence
- Casitas B-lineage lymphoma proto-oncogene
- CBL
- CBL2
- CBL2E3 ubiquitin-protein ligase CBL
- EC 6.3.2
- EC 6.3.2.-
- oncogene CBL2
- Proto-oncogene c-Cbl
- RING finger protein 55
- RNF55
- RNF55C-CBL
- Signal transduction protein CBL
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Related CBL Blog Posts
Check out the latest blog posts on CBL.
CD19: An Undoubted Biomarker for B Cells
CD19 is a cell surface protein member of the large immunoglobulin superfamily that complexes with CD21, CD81, and CD225 in the membrane of mature B-cells. A major function of CD19 is to assemble with the antigen receptor of B-lymphocytes to decrease t... Read more.
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Read more CBL related blogs.
![Western Blot CBL Antibody [Unconjugated]](http://images.novusbio.com/fullsize2/CBL_AF5998_Western_Blot_9528.jpg)
![Simple Western CBL Antibody [Unconjugated]](http://images.novusbio.com/fullsize/antibody/af5998_human-mouse-cbl-affinity-purified-polyclonal-ab-simple-western-2772023104618..jpg)
