Casein Kinase 1 alpha Products

Description

Casein kinase I (also designated CKI) and casein kinase II (CKII) compose a family of serine/threonine protein kinases which are present in all eukaryotes examined to date. Casein kinase I family members, which include casein kinase Ialpha, Igamma, Idelta and Iepisilon, have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. CKII is usually expressed as a tetrameric complex consisting of either an alpha2beta2 or an alphaalpha'beta2 structure. The a catalytic subunit is stimulated by the beta regulatory subunit, which undergoes autophosphorylation. Casein kinase II activity is high in the cytosol and nucleus of proliferating and differentiating cells. Casein kinase II is known to phosphorylate more than 100 different substrates including nuclear oncoproteins, transcription factors and enzymes involved in DNA metabolism.

Bioinformatics

Entrez	113927 Rat 1452 Human 93687 Mouse
Uniprot	AAH08717 Human DQ082865 Human NP_001020276 Human NP_001883 Human NP_001883.4 Human P48729 Human
Product By Gene ID	1452
Alternate Names	casein kinase 1, alpha 1 casein kinase I isoform alpha CK1CKI-alpha down-regulated in lung cancer EC 2.7.11.1 HLCDGP1 PRO2975

Research Areas for Casein Kinase 1 alpha

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Protein Kinase
Wnt Signaling Pathway