c-jun Products

Description

Genes belonging to the Jun and Fos oncogene families encode nuclear proteins that are found to be associated with a number of transcriptional complexes. The c-Jun protein is a major component of the transcription factor AP-1, originally shown to mediate phorbol ester tumor promoter (TPA)-induced expression of responsive genes through the TPA-response element (TRE). The Jun proteins form homo- and heterodimers which bind the TRE, but the Fos proteins are active only as heterodimers with any of the Jun proteins. Fos/Jun heterodimers have a much higher affinity for the TRE than Jun homodimers. Ha-Ras augments c-jun activity and stimulates phosphorylation of its activation domain. An inhibitor of Fos/Jun function, termed IP-1, associates with Fos and Jun and is deactivated upon phosphorylation induced by the cAMPdependent protein kinase A (PKA).

Bioinformatics

Entrez	3725 Human 24516 Rat
Product By Gene ID	3725
Alternate Names	Activator protein 1 AP1 AP-1 cJun c-Jun enhancer-binding protein AP1 Jun activation domain binding protein jun oncogene jun proto-oncogene JUN Proto-oncogene c-Jun transcription factor AP-1 V-jun avian sarcoma virus 17 oncogene homologp39 v-jun sarcoma virus 17 oncogene homolog (avian) v-jun sarcoma virus 17 oncogene homolog

Research Areas for c-jun

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cell Cycle and Replication
Hypoxia
Immunology
Innate Immunity
Phospho-Specific
Signal Transduction
Transcription Factors and Regulators
Tumor Suppressors
Wnt Signaling Pathway

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Estrogen Related Receptors Play Roles in Cancer and Neurodegeneration By Eric NeeleyEstrogen receptors come in the form of two distinct forms, ER alpha and ER beta. These nuclear receptors are predominantly activated by the hormone 17-beta-estradiol to control transcription of genes throughout the immune, nervous, car...    Read more.

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