B7-H4 Products

Description

B7H4 is a costimulatory protein which is reported to function as a negative regulator of T-cell mediated immunity. Although B7H4 binds an unknown receptor, it is thought to deliver an inhibitory signal to T-cells preventing their proliferation, cell cycle progression and interleukin-2 production. B7H4 deficient mice are only minimally affected, thus suggesting B7H4 is important in the fine tuning of the T-cell mediated immune response. B7H4 is expressed on activated T-cells, B-cells, monocytes and dendritic cells. Aberrant expression has been associated with cancers of the lung, breast and ovary in humans. B7H4 could be a useful prognostic marker in Renal Cell Carcinoma (RCC). There are three different isoforms.

Bioinformatics

Entrez	242122 Mouse 295322 Rat 79679 Human
Uniprot	NM_024626 Human NP_078902.2 Human Q7Z7D3 Human
Product By Gene ID	79679
Alternate Names	B7h.5 B7-H4 B7H4T-cell costimulatory molecule B7x B7S1VCTN1 B7XPRO1291 FLJ22418 Immune costimulatory protein B7-H4 Protein B7S1 T cell costimulatory molecule B7x V-set domain containing T cell activation inhibitor 1 V-set domain-containing T-cell activation inhibitor 1