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VEGF R2/KDR/Flk-1

HIF-3 alpha: a versatile target with hypoxia dependent and independent functions

By: Subhash Gangar

Tags: 
HIF-3 alpha
HIF-1 alpha
HIF-2 alpha
ARNT/HIF-1 beta
NF-kB
Ets-1
Tie2
VEGF R2/KDR/Flk-1
Angiopoietin-2/Ang2

VEGFR-2 - A highly active kinase

VEGFR-2 is a family member of the vascular endothelial growth factor (VEGF) family of membrane receptor tyrosine kinases. It is a key regulator of the process of angiogenesis that takes place during fundamental developmental processes such as embryogenesis, skeletal growth, and reproductive functions. Like other growth factor receptors, upon ligand binding, VEGFR2 dimerizes and is autophosphorylated on multiple tyrosine residues.

Tags: 
Angiogenesis
VEGFR-2 antibody
periostin
HIF-1
HGF
VEGF R2/KDR/Flk-1