GSK

Beta-catenin is a cytosolic, 88 kDa intracellular protein associated with cell surface cadherin glycoproteins. It is a member of the larger calcium-dependent catenin family that includes alpha-catenin, beta-catenin, and gamma-catenin (also known as plakoglobin). Beta-catenin enters the nucleus to interact with TCF/LEF (Lymphoid enhancer factor-1) transcription factor family. It is normally inhibited by the GSK (glycogen synthase kinase) or CK1 (casein kinase 1) as phosphorylation of beta-catenin targets it for ubiquitin-mediated degradation.

Beta Catenin is a cytosolic, 88 kDa intracellular protein that tightly associates with cell surface cadherin glycoproteins. It is one member of the catenin family that includes alpha Catenin, beta Catenin, and gamma Catenin. Colocalization studies using beta-catenin antibodies demonstrate that beta-catenin is a crucial link between cytoplasmic, cytoskeletal actin and transmembrane cadherin for tight cell-to-cell adhesion (1,2).