CD8

Integrins are transmembrane receptors composed of alpha and beta chains, where beta-integrins are mainly expressed in leukocytes. Leukocytes are white blood cells that act in the immune system to defend our body against foreign pathogens.

CD20 is a human B-lymphocyte surface molecule that spans the membrane four times and is expressed on both normal and malignant cells. The CD20 antigen displays a unique expression pattern among hematopoietic cells - it is present on human pre B-lymphocytes and B-lymphocytes at all stages of maturation (except for plasma cells). Low CD20 antigen expression levels have been detected on normal T-lymphocytes. It functions as a B-cell activation receptor and B-lymphocyte development and differentiation agent, presumably through modulating intracellular calcium levels.

What is CD8?

CD4 is a member of the cluster of differentiation family of proteins, mainly expressed on the surface of thymocytes and a specific subset of mature T-cells. CD4 antibody studies have also shown it expressed on monocytes, cortical cells, microglial cells, dendritic cells and macrophages. The CD4 antibody is widely used in cell marker studies, CD4 being one of the most common CD markers in use.