HSP70 family member GRP78 (78 kD glucose-regulated protein) is an abundant protein cofactor commonly known as a molecular chaperone. Found in most eukaryotes, Hsp genes are members of a heat-inducible multigene family.
The neurokinin 1 receptor (NK1), commonly referred to as tachykinin receptor 1, is a 401 amino acid, 46 kDA protein encoded by the TACR1 gene localized on chromosome 2 (2p13.1-p12).
Actins are extremely highly conserved structural proteins found in all eukaryotic cell cytoskeletons that govern cell structure, movement, and shape integrity. Six distinct actin isoforms, each encoded by a different gene and developmentally-regulated as well as tissue-specific-regulated, have been identified in mammalian cells. The alpha and beta isotypes are cytoplasmic and expressed in a wide variety of cells.
70-kDa Heat Shock Protein (Hsp70) is an abundant protein cofactor commonly known as a molecular chaperone. Found in most eukaryotes, Hsp genes are members of a heat-inducible multigene family. These proteins are found in most cellular compartments of eukaryotes - everything from nuclei, mitochondria, chloroplasts, to endoplasmic reticulum and cytosol.
Caveolin-1 (CAV1) belongs to the caveolin family of integral membrane proteins 21-24 kD in size. This family of proteins forms the structural component of the caveolar membrane in caveolae, which are the specialized domains in plasma membrane that sequester lipids and proteins.
Gap junctions consist of Connexins (Cx), a family of proteins that form channels linking the cytoplasm of adjacent cells. All Connexin molecules have four membrane-spanning domains, two extracellular domains, and a cytoplasmic carboxy-terminal tail of varying length that has an important role in the regulation of the gating properties of the channel. Interestingly Connexin 43 also known as gap junction alpha-1 protein is one of the most abundant gap-junction protein.
Actin is a ubiquitous and an essential component of the cytoskeleton, with critical roles in a wide range of cellular processes. It is abundant protein whose monomers polymerize into polarized actin filaments, within epithelial cells. Filamentous actin is concentrated at the plasma membrane where a wide variety of actin-associated proteins harness the potential and structure of actin filaments to moderate functions at the plasma membrane (1).
EEA1, or Early Endosome Antigen 1 is a Rab5 effector essential for early endocytic membrane fusion. The EEA1 antibody is used in membrane trafficking and chaperone studies, and as an endosome marker. We at Novus Biologicals have a comprehensive antibody catalog of EEA1 products.
The SLC26A3, also known as DRA (downregulated-in-adenoma) gene is a member of the sulphate anion transporter family, serving an important role in the exchange and transport of chloride, bicarbonate and sulphate ions at plasma membrane sites. We at Novus offer a growing selection of antibodies, recombinant proteins, lysates and RNAi for SLC26A3 within our reagent database.
