Blogs for February 2022

Synthetic Biotic Medicine as Immunotherapy Against Cancer: Evidence From Arginine-Producing Engineered Bacteria

Tuesday, February 1, 2022 - 09:12
3D banner image showing example of pathogenic bacteria.

By Jamshed Arslan, Pharm D, PhD

What do nuts, dairy and red meat have in common? In addition to the fact that they are all edible, one of the answers is L-arginine. This amino acid improves T cell’s response against tumor cells, which typically have low concentration of L-arginine. Increasing L-arginine intra-tumorally, in turn, increases the effect of immunotherapy drugs called immune checkpoint inhibitors (ICIs). To understand ICIs, consider two examples of...

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