Blogs for January 2021

COVID-19-Related Neurological Problems: Uncovering the Mechanisms

Monday, January 11, 2021 - 10:41
Novus Biologicals 3D image for coronavirus banner

By Jamshed Arslan, Pharm D, PhD

There is good news and bad news related to COVID-19, a disease caused by SARS-COV-2 infection. Good news first: the vast majority of otherwise healthy individuals remain asymptomatic. The bad news though is that even the asymptomatic population is at risk for COVID-19-related brain damage called NeuroCOVID. The neurological manifestations related to COVID-19 may be less severe and less frequent in milder cases as compared to the hospitalized patients. This article will outline the mechanism behind NeuroCOVID and COVID-19-related neuropsychological...

Breast cancer stem cells survive chemotherapy through S100A10-ANXA2-SPT6 interaction that epigenetically promotes OCT4-mediated stemness

Wednesday, January 6, 2021 - 15:38
Immunohistochemical staining of paraffin-embedded human breast carcinoma with rabbit polyclonal Oct4 antibody.

By Jamshed Arslan, Pharm D, PhD

Breast cancer is the most common cancer among women that causes the greatest number of cancer-related deaths worldwide. After radiotherapy or cytotoxic chemotherapy like paclitaxel, the surviving breast cancer stem cells (BCSCs) lead to tumor recurrence and metastasis. Resistant BCSCs undergo self-renewal and multi-lineage differentiation similar to embryonic stem cells (ESCs). The master regulators for such...

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