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By Jamshed Arslan, Pharm. D., PhD.
The hypothalamus is an insulin receptor-rich brain region. Insulin receptor signaling in the CNS can regulate blood pressure, for example, by increasing sympathetic outflow to the cardiovascular organs. However, the cardiometabolic impact of deleting insulin receptors only in the hypothalamic region is different from deleting insulin receptors in the whole brain. In other words, insulin signaling outside the hypothalamus is also important for cardioregulatory activities. To explore this extra-hypothalamic insulin signaling, scientists from...
