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By Michalina Hanzel, PhD
In a series of three blog posts I will briefly explore the major cellular mechanisms responsible for many neurodegenerative disorders. The first, and perhaps the most apparent, is the accumulation of misfolded, aggregate-prone proteins, as a result of a failure of the autophagy system, which leads to the loss of neuronal structure and function and eventual neuronal loss.
Autophagy is a conserved cellular process used to eliminate obsolete proteins and cell components by degradation and...
