 Novus antibodies have been cited over 1,300 times in research relating to breast cancer and its associated diseases. We are proud to offer high quality antibodies that help researchers probe the underlying causes and possible treatments for breast cancer patients. Cited Novus Antibodies for Breast Cancer Research
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Endoglin/CD105 is a single-pass type I membrane protein which is characteristically found in the vascular endothelial linings. It is a disulfide-linked homodimeric glycoprotein of 180-kDa size and besides endothelial cells, it is also expressed in mesangial cells, cardiac and scleroderma fibroblasts, hepatic stellate cells etc. CD105 acts as a co-receptor for TGF beta and it implicates in TGF beta/BMP as well as GDF2/BMP9 signaling pathways. CD105 plays key roles in angiogenesis and vasculogenesis during development, and in neo-angiogenesis during tumor growth. CD105 has become an established and specific marker of novel angiogenic vessels. Several mutations of the endoglin gene ENG are now known which links to hereditary hemorrhagic telangiectasia type-I /HHT-1 or Rendu-Osler-Weber syndrome. ... |
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Histone H3 is a key protein in the studies of epigenetics. The protein consists of a globular domain and a flexible N-terminal tail; the tail protrudes from the nucleosome and is the site of a huge diversity of post-translational modifications that support the maintenance of an active or inactive transcriptional state. Numerous modifications of histone H3 are known, including methylation or acetylation of arginine or lysine residues, and phosphorylation of serine or threonine residues; these modifications may promote or inhibit transcription. Histone H3 (1B1-B2)... |
