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New LC3 Monoclonal Antibodies

LC3 protein (microtubule-associated protein light chain 3) is the most studied biomarker of autophagy, the self-eating cell death process which implicates in several physiological and pathological processes such as responses to exercise, aging, cancer, myopathy, cardiovascular/pulmonary diseases, and metabolic and neurodegenerative disorders.

Novus has recently launched two rabbit monoclonal anti-LC3 antibodies (NBP2-46888 and NBP2-46892). NBP2-46888 (clone 1712D) shows cross reactivity with both LC3A and LC3B while NBP2-46892 (clone 1251A) is specific for LC3B. They have been...

Antibodies for Apoptosis Signaling

Apoptosis is an evolutionarily conserved mechanism of cell death which plays a critical role in tissue development and homeostasis. Excessive apoptosis can lead to degenerative diseases, while losing the ability to undergo apoptosis can result in uncontrolled cellular proliferation/growth or cancer. At the molecular level, apoptosis is executed via intrinsic/mitochondrial and extrinsic/death receptor pathways through a precise interplay between several signaling proteins, especially the initiator (8, 9, 10 and 12) and the effector (3, 6 and 7) caspases as illustrated below:

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Antibody Panels for Cell Proliferation Research
Antibody Panels for Cell Proliferation Research

In living organisms, cell proliferation is an integral part of growth and homeostasis as well as disease development (especially cancer). At the molecular level, proliferation is precisely regulated through cell cycle, the period between successive divisions of a cell. Cell cycle is consists of two phases, interphase (Gap1/G1, Synthesis/S, Gap2/G2) and mitotic/M phase, which are...

Epithelial-Mesenchymal Transition Signaling Related Antibodies
EMT Related Antibodies

Epithelial-Mesenchymal Transition (EMT) is the transdifferentiation of stationary epithelial cells into motile mesenchymal cells. During EMT, epithelial cells lose their junctions and apical–basal polarity, reorganize their cytoskeleton, undergo a change in the signalling programmes that define cell shape and reprogramme gene expression; this increases the motility of individual cells and enables the development...

Antibody Reproducibility Inititative

Novus Reproducibility Initiative


Antibody validation and reproducibility are major concerns for life sciences researchers. Antibody-based experiments have been published in hundreds of journals and thousands of articles, yet the validation results for individual antibodies are rarely included with the article results. Novus recognizes the need for independently validated, peer reviewed data about antibody performance and reproducibility.

As part of our Antibody Reproducibility Initiative, we are sponsoring...

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