Novus has recently added a new mouse monoclonal antibody against the transmembrane receptor “Notch1”. Notch signaling is vital to cell fate specification during development via regulation of interactions between adjacent cells. Read below to see if this new product will accelerate your research!
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Angiogenesis is an essential process during normal tissue growth and in response to wound healing. It is vital for the development of new connective tissue and small blood vessels from pre-existing vessels. Additionally, due to the mechanisms of angiogenesis, it is also a major step in the transition and proliferation of malignant tumors from benign states. |
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Cathepsin B is a lysosomal cysteine protease belonging to the peptidase C1 family. The protein is expressed in luminal epithelial cells and its expression indicates that Cathepsin B is a marker for secretory cell death. Recent studies found that Cathepsin B facilitates autophagy-mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells. The enzyme also contributes to Atg7-induced pro-inflammatory response in Rat insulinoma cell line. And inhibition of Cathepsins B and L induce autophagy and cell death in neuroblastoma cells. |
