Spotlight on WNK1, MRP1 and Podocalyxin in ion transport The WNK kinases have been shown to play an essential role in several cellular processes such as ion balance, signal transduction, and proliferation etc. WNK1 is a member of the WNK family of serine-threonine kinases and appears to be important to ion homeostasis. Mutations in WNK1 (large intronic deletions) cause Gordon’s syndrome, an autosomal dominant disease characterized by defects in ion transport in the nephron that result in hypertension and hyperkalemia. MRP1 (Multidrug Resistance associated Protein 1) is an integral membrane glycophosphoprotein belonging to the family of ATP-Binding Cassette (ABC)... |
