Species: Hu, Mu, Rt, Pm
Applications: WB, Simple Western, ELISA, Flow, ICC/IF
Host: Mouse Monoclonal
Species: Hu
Applications: ICC/IF, ChIP
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, ICC/IF
Host: Rabbit Monoclonal
Species: Hu
Applications: ELISA
Description
Telomeric repeat binding factor 1 (TRF1, TERF1, PIN2, TRBF1) and telomeric repeat binding factor 2 (TRF2, TERF2, TRBF2) are present at telomeres throughout the cell cycle, where they regulate telomerase by acting in cis to limit the elongation of individual chromosome ends. Telomerase adds hexameric repeats of TTAGGG to the ends of chromosomal DNA. This telomerase enzyme plays an influential role in cellular immortalization and cellular senescence. TRF1 negatively regulates telomere elongation, while TRF2 protects the chromosome ends by inhibiting end-to-end fusions. Downregulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression. TRF1 has an acidic N-terminus while TRF2 has a basic N-terminus. TRF2 localizes in the nucleolus at G0 and S and diffuses out of the nucleolus in G2 phase. During mitosis TRF2 disperses from the condensed chromosomes and returns to the nucleolus at cytokinesis.
Bioinformatics
| Product By Gene ID |
7013 |
| Alternate Names |
- NIMA-interacting protein 2
- PIN-2
- PIN2hTRF1-AS
- Telomeric protein Pin2/TRF1
- telomeric repeat binding factor (NIMA-interacting) 1
- telomeric repeat binding factor 1
- telomeric repeat binding protein 1
- telomeric repeat-binding factor 1
- TERF1
- TRBF1
- TRF1
- TRF-1
- TRF1FLJ41416
- TRFt-TRF1
- TTAGGG repeat-binding factor 1
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