TRAF-2 Products

Description

The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis. TRAF2 is typically described as a 501 amino acid (aa) protein, GenBank no. NP_066961.2. However, various TRAF2 isoforms have been described. Therefore the molecular weight of TRAF2 detected by Western blot may vary depending on isoforms expressed.

Bioinformatics

Entrez	22030 Mouse 7186 Human
Uniprot	AAH43492 Human CAI15106 Human NM_021138 Human NP_066961 Human NP_066961.2 Human P39429 Mouse Q12933 Human
Product By Gene ID	7186
Alternate Names	E3 ubiquitin-protein ligase TRAF2 EC 6.3.2.- MGC:45012 TNF receptor-associated factor 2 TRAP3TRAP tumor necrosis factor type 2 receptor associated protein 3 Tumor necrosis factor type 2 receptor-associated protein 3

Research Areas for TRAF-2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cytokine Research
Zinc Finger