TRADD Products

Description

The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway.

Bioinformatics

Entrez	8717 Human
Uniprot	NP_003780 Human
Product By Gene ID	8717
Alternate Names	MGC11078 TNFRSF1A-associated via death domainTNFR1-associated DEATH domain protein TRADD tumor necrosis factor receptor type 1 associated death domain protein tumor necrosis factor receptor type 1-associated DEATH domain protein tumor necrosis factor receptor-1-associated protein

Research Areas for TRADD

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Tumor Suppressors

Related TRADD Blog Posts

Check out the latest blog posts on TRADD.

Caspase 9: The Suicidal Cell Whisperer Cell death via apoptosis is a key cellular function triggered by the cell death receptor family and their ligands which signal through downstream adaptor molecules and the caspase protease family. Among the subclass of initiator caspases that include ...    Read more.

Read more TRADD related blogs.