Species: Hu, Mu, Rt
Applications: WB, Func, ICC/IF, IHC
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Description
GPR91 (formerly known as P2U2) is a G protein-coupled, dicarboxylic acid succinate receptor with the highest level of expression in the kidney, predominantly in the proximal tubules and the lowest in the liver and the spleen. GPR91 functions as a citric acid cycle intermediate succinate receptor. Two signaling pathways result from GPR91 activation, the pertussis-toxin-sensitive Gi/Go pathway and the pertussis-toxin-insensitive Gq pathway. Four amino acid residues are necessary for GPR91 activation by succinate: Arg 99, His 103, Arg 252 and Arg 281. GPR91 plays an important role in the succinate-induced hypertensive effect and may be involved in renovascular hypertension, a disease linked to diabetes, renal failure and atherosclerosis.
Bioinformatics
| Entrez |
Human
Rat
|
| Uniprot |
Human
|
| Product By Gene ID |
56670 |
| Alternate Names |
- GPR91
- GPR91G protein-coupled receptor 91
- G-protein coupled receptor 91
- P2Y purinoceptor 1
- P2Y purinoceptor 1-like
- succinate receptor 1
- SUCNR1
|
Research Areas for SUCNR1/GPR91
Find related products by research area and learn more about each of the different research areas below.
GPCR
