SIRP alpha/CD172a Products

Description

Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPa (1), SHPS-1 (2,3), MyD-1 (4), BIT (5,6) and p84 (7). SIRPa is a new gene family containing at least fifteen members. SIRPa is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2 (1,2,5,8). SIRPa has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes (1,2,5,8).

Bioinformatics

Entrez	140885 Human 19261 Mouse 25528 Rat
Uniprot	AAH26692 Human AAH33092.1 Human NM_001040022 Human NP_001035112 Human NP_542970 Human P78324 Human P97710 Rat
Product By Gene ID	140885
Alternate Names	Bit BITbrain-immunoglobulin-like molecule with tyrosine-based activation motifs Brain Ig-like molecule with tyrosine-based activation motifs CD172 antigen-like family member A CD172a antigen CD172a Inhibitory receptor SHPS-1 Macrophage fusion receptor MFRtyrosine phosphatase SHP substrate 1 MyD-1 antigen MYD1 MYD-1 P84 p84 protein tyrosine phosphatase, non-receptor type substrate 1 PTPNS1 SHP substrate 1 SHPS-1 SHPS1CD172A signal-regulatory protein alpha Signal-regulatory protein alpha-1 Signal-regulatory protein alpha-2 Signal-regulatory protein alpha-3 SIRPalpha SIRP-ALPHA-1 Sirp-alpha-1 SIRPalpha2 Sirp-alpha-2 Sirp-alpha-3 SIRPtyrosine-protein phosphatase non-receptor type substrate 1

Research Areas for SIRP alpha/CD172a

Find related products by research area and learn more about each of the different research areas below.

GPCR
Protein Phosphatase
Signal Transduction