RB1 Products

Description

Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F1, PU1, ATF2, UBF, Elf1 and cAbl. This ability of Rb to alter transcription is regulated by phosphorylation catalyzed by the cyclin dependent protein kinases (cdks). Rb is phosphorylated on serine and threonine, but not on tyrosine residues. It forms a complex with SV40 large T antigen, adenovirus E1A, and human papilloma virus 16E. Rb protein may act by regulating transcription and loss of its function leads to uncontrolled cell growth. Aberrations in the Rb gene have been implicated in cancers of breast, colon, prostate, kidney, nasopharynx, and leukemia.

Bioinformatics

Entrez	5925 Human 19645 Mouse 24708 Rat
Uniprot	P06400
Product By Gene ID	5925
Alternate Names	OSRC osteosarcoma p105-Rb pp110 pRb Rb RB1 retinoblastoma 1 retinoblastoma suspectibility protein retinoblastoma-associated protein

Research Areas for RB1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Phospho-Specific
Transcription Factors and Regulators
Tumor Suppressors