TLR11 Antibody (786404) [DyLight 488]

• Reactivity: Mu
• Applications: CyTOF-ready, Flow
• Clone: 786404
• Clonality: Monoclonal
• Host: Rat
• Conjugate: DyLight 488

TLR11 Antibody (786404) [DyLight 488] Summary

• Immunogen: E. coli-derived recombinant mouse TLR11
  Thr209-Gln325
  Accession # Q6R5P0
• Specificity: Detects mouse TLR11 in direct ELISAs.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Rat
• Gene: TLR11
• Purity: Protein A or G purified from hybridoma culture supernatant

Applications/Dilutions

• Dilutions:
  • CyTOF-ready
  • Intracellular Staining by Flow Cytometry
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified from hybridoma culture supernatant

Notes

DyLight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.

Alternate Names for TLR11 Antibody (786404) [DyLight 488]

• Gm287
• hgnc31753
• TLR11
• Toll like receptor 11

Background

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors. TLR11 is one of three mouse TLRs that lack a human ortholog. It is activated specifically by uropathogenic bacteria, and mice lacking TLR11 showed a much greater susceptability to uropathogenic infections, indicating a potentially important role for TLR11 in preventing infections in the urogenital system.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: TLR11