SARS-CoV-2 Spike Antibody (D005) Summary
Recombinant SARS-CoV Spike RBD Protein
Protein A purified
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Packaging, Storage & Formulations
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
0.2 um filtered solution in PBS
Protein A purified
This SARS-CoV-2 Spike Antibody (D005) is a chimeric monoclonal antibody combining the constant domains of human IgG1 with mouse variable regions.
Alternate Names for SARS-CoV-2 Spike Antibody (D005)
- 2019-nCoV S Protein
- 2019-nCoV Spike
- COVID-19 Spike
- Human coronavirus spike glycoprotein
- SARS-COV-2 S protein
- SARS-COV-2 Spike glycoprotein
- SARSCOV2 Spike protein
- Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein
- Spike glycoprotein
Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). Seven coronaviruses had been found to cause human infection including SARS-CoV-2/2019-nCoV resulting in a potentially fatal atypical pneumonia, named COVID-19. SARS-CoV-2 has 4 major structural proteins including spike (S), envelope (E), membrane (M), and nucleocapsid (N), which share significant sequence homology with SARS-CoV. The spike protein in SARS-CoV-2 (1,273 aa) is a viral surface glycoprotein. Research on SARS-host protein interactions with SARS-CoV and SARS-CoV-2 viruses have shown that the viral spike (S) protein binds human ACE-2 located on the surface of mucosal cells, resulting in fusion of viral and cell membranes for viral entry. Viral entry also requires priming of the S protein by host cell proteases such as TMPRSS2, Cathepsin L or furin. The Coronavirus Spike precursor protein is processed into 2 distinct subunits with S1 (654 aa) housing the receptor binding domain (RBD) and S2 (588 aa or 458 a) facilitating membrane fusion.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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