SARS-CoV-2 Spike Antibody (D005)

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Product Details

Summary
Reactivity VSpecies Glossary
Applications ELISA
Clone
D005
Clonality
Monoclonal
Host
Human
Conjugate
Unconjugated

Order Details

SARS-CoV-2 Spike Antibody (D005) Summary

Immunogen
Recombinant SARS-CoV Spike RBD Protein
Isotype
IgG1
Clonality
Monoclonal
Host
Human
Purity
Protein A purified
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Applications/Dilutions

Dilutions
  • ELISA

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.2 um filtered solution in PBS
Preservative
No Preservative
Purity
Protein A purified

Notes

This SARS-CoV-2 Spike Antibody (D005) is a chimeric monoclonal antibody combining the constant domains of human IgG1 with mouse variable regions.

Alternate Names for SARS-CoV-2 Spike Antibody (D005)

  • 2019-nCoV S Protein
  • 2019-nCoV Spike
  • COVID-19 Spike
  • Human coronavirus spike glycoprotein
  • SARS-COV-2 S protein
  • SARS-COV-2 Spike glycoprotein
  • SARSCOV2 Spike protein
  • Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein
  • Spike glycoprotein
  • Spike

Background

Coronaviruses are positive-stranded RNA viruses, featuring the largest viral RNA genomes known to date (27-31 kb). Seven coronaviruses had been found to cause human infection including SARS-CoV-2/2019-nCoV resulting in a potentially fatal atypical pneumonia, named COVID-19. SARS-CoV-2 has 4 major structural proteins including spike (S), envelope (E), membrane (M), and nucleocapsid (N), which share significant sequence homology with SARS-CoV. The spike protein in SARS-CoV-2 (1,273 aa) is a viral surface glycoprotein. Research on SARS-host protein interactions with SARS-CoV and SARS-CoV-2 viruses have shown that the viral spike (S) protein binds human ACE-2 located on the surface of mucosal cells, resulting in fusion of viral and cell membranes for viral entry. Viral entry also requires priming of the S protein by host cell proteases such as TMPRSS2, Cathepsin L or furin. The Coronavirus Spike precursor protein is processed into 2 distinct subunits with S1 (654 aa) housing the receptor binding domain (RBD) and S2 (588 aa or 458 a) facilitating membrane fusion.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for SARS-CoV-2 Spike Antibody (NBP2-90989) (0)

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Product General Protocols

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FAQs for SARS-CoV-2 Spike Antibody (NBP2-90989) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 350 NBP2-90989AF350
Alexa Fluor 405 NBP2-90989AF405
Alexa Fluor 488 NBP2-90989AF488
Alexa Fluor 532 NBP2-90989AF532
Alexa Fluor 594 NBP2-90989AF594
Alexa Fluor 647 NBP2-90989AF647
Alexa Fluor 700 NBP2-90989AF700
Alexa Fluor 750 NBP2-90989AF750
Allophycocyanin NBP2-90989APC
Biotin NBP2-90989B
DyLight 350 NBP2-90989UV
DyLight 405 NBP2-90989V
DyLight 488 NBP2-90989G
DyLight 550 NBP2-90989R
DyLight 594 NBP2-90989DL594
DyLight 650 NBP2-90989C
DyLight 680 NBP2-90989FR
DyLight 755 NBP2-90989IR
FITC NBP2-90989F
HRP NBP2-90989H
Janelia Fluor 549 NBP2-90989JF549
Janelia Fluor 646 NBP2-90989JF646
PE NBP2-90989PE
PerCP NBP2-90989PCP

Additional SARS-CoV-2 Spike Products

Blogs on SARS-CoV-2 Spike

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Coronavirus Brochure

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Contact Information

Learn the difference between western blot and simple western

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Calculators

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