Oval Cell Marker Antibody (OC2-2A6)

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Immunohistochemistry: Oval Cell Marker Antibody (OC2-2A6) [NBP1-18967] - Analysis of DDC treated mouse liver.

Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, ICC/IF, IHC, IHC-Fr
Clone
OC2-2A6
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
This product is unpurified. The exact concentration of antibody is not quantifiable.

Oval Cell Marker Antibody (OC2-2A6) Summary

Immunogen
Nonparenchymal cells from DDC-treated mice to induce the oval cell response.
Localization
Cell surface
Marker
Hepatic periductal cell Marker
Specificity
Specific for proliferating hepatic periductal cells.
Isotype
IgG1
Clonality
Monoclonal
Host
Rat
Purity
Tissue culture supernatant
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:50-1:100
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry 1:100
  • Immunohistochemistry-Frozen 1:100
Application Notes
This Oval Cell Marker (OC2-2A6) antibody is useful for Immunohistochemistry on acetone fixed frozen sections and Flow cytometry. Immunocytochemistry/Immunofluorescence was reported in scientific literature.
Publications
Read Publications using
NBP1-18967 in the following applications:

Reactivity Notes

Mouse.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
No buffer
Preservative
0.09% Sodium Azide
Concentration
This product is unpurified. The exact concentration of antibody is not quantifiable.
Purity
Tissue culture supernatant

Notes

The estimated concentration for this antibody is 1.0 mg/ml.

Alternate Names for Oval Cell Marker Antibody (OC2-2A6)

  • macrophage inhibitory cytokine-1

Background

Liver is well known to possess facultative stem cells which can be activated in response to injury and hepatic stem cell activation was first described in rat model, wherein, chemical damage in combination with partial hepatectomy resulted in the emergence of a new cell type which was described according to its nuclear morphology as "oval cells". The word 'oval cells' is now employed to define population of small proliferating cells with oval-shaped nuclei which arise within liver tissue following certain types of hepatic injury. Oval cell proliferation is activated when the proliferative capacity of hepatocytes is impaired, as well as in certain models of carcinogenesis. Histologically, hepatic tissue is highly complex and contains many different cell types including various kinds of hepatocytes, ducts, hematopoietic cells, endothelial cells, macrophages, stellate cells etc., and the oval cells have been proposed to be bipotential progenitor cells capable of generating both hepatocytes and bile ducts. Due to their bipotency and high clonogenicity, oval cells have been considered putative liver stem cells and research is in progress for elucidation of signaling molecules involved in controlling the activation, proliferation and differentiation of this unique cell population. Our oval cell antibodies have been developed against hepatic nonparenchymal cells (NPCs) from mice undergoing oval cell activation and with these antibodies, it is now possible to perform microarray analysis of distinct liver cell populations during induced oval cell response or certain pathological conditions.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for Oval Cell Marker Antibody (NBP1-18967)(2)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 3 applications: FLOW, ICC/IF, IHC-Fr.


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FLOW
(1)
ICC/IF
(1)
IHC-Fr
(1)
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Mouse
(2)
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Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Alexa Fluor 405 Labeled NBP1-18967AF405
Alexa Fluor 488 Labeled NBP1-18967AF488
Alexa Fluor 647 Labeled NBP1-18967AF647
Alexa Fluor 700 Labeled NBP1-18967AF700
Allophycocyanin Labeled NBP1-18967APC
Biotin Labeled NBP1-18967B
DyLight 350 Labeled NBP1-18967UV
DyLight 405 Labeled NBP1-18967V
DyLight 488 Labeled NBP1-18967G
DyLight 550 Labeled NBP1-18967R
DyLight 650 Labeled NBP1-18967C
DyLight 680 Labeled NBP1-18967FR
DyLight 755 Labeled NBP1-18967IR
FITC Labeled NBP1-18967F
HRP Labeled NBP1-18967H
PE Labeled NBP1-18967PE
PerCP Labeled NBP1-18967PCP

Additional Oval Cell Marker Products

Oval Cell Marker NBP1-18967

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