ORF73/HHV8 Antibody (LN53) [Alexa Fluor® 647]

• Reactivity: V-Vi
• Applications: ELISA, IHC
• Clone: LN53
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 647

ORF73/HHV8 Antibody (LN53) [Alexa Fluor® 647] Summary

• Immunogen: Recombinant protein corresponding to the latent nuclear antigen-1 molecule of HHV8.
• Localization: Nuclear
• Specificity: This antibody reacts with ORF-73 of human Herpes virus 8 (HHV8). HHV8 is the likely etiological agent of Kaposi's sarcoma (KS). HHV8 encodes a latent nuclear antigen (LNA) which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product which may be related to its oncogenic activity.
• Isotype: IgG2c
• Clonality: Monoclonal
• Host: Rat
• Gene: HHV8GP78
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunoassay
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: Optimal dilution of this antibody should be experimentally determined.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

Alexa Fluor (R) products are provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or outlicensing@lifetech.com. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for ORF73/HHV8 Antibody (LN53) [Alexa Fluor® 647]

• HHV8GK18_gp81
• LANA
• LANA1
• LNA
• ORF73

Background

HHV8 has been found to be associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV8 in kaposi's sarcoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HHV8GP78