ORF73/HHV8 Antibody (LN53) [Janelia Fluor® 525]

• Reactivity: V-Vi
• Applications: ELISA, IHC
• Clone: LN53
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Janelia Fluor 525

ORF73/HHV8 Antibody (LN53) [Janelia Fluor® 525] Summary

• Description: This conjugate is made on demand and is not held in inventory. Each order represents a unique lot. All conjugates are generated using validated conjugation protocols and meet strict degree of labeling (F/P) specifications; additional information is available upon request. The antibody concentration is provided on the individual product label.
  
  For specialized conjugation needs, like large quantities, specific concentrations, and defined F/P ratios, bulk and custom antibody conjugation services are available.
• Immunogen: Recombinant protein corresponding to the latent nuclear antigen-1 molecule of HHV8.
• Localization: Nuclear
• Specificity: This antibody reacts with ORF-73 of human Herpes virus 8 (HHV8). HHV8 is the likely etiological agent of Kaposi's sarcoma (KS). HHV8 encodes a latent nuclear antigen (LNA) which is the product of the viral gene orf 73. LNA is capable of forming a complex with retinoblastoma susceptibility gene product which may be related to its oncogenic activity.
• Isotype: IgG2c
• Clonality: Monoclonal
• Host: Rat
• Gene: HHV8GK18_gp81
• Purity: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunoassay
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
• Application Notes: Recommended applications are based on validated applications from the unconjugated base product NBP1-22767. This conjugated antibody is not kept in inventory and is made to order using validated conjugation protocols.

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: 50mM Sodium Borate
• Preservative: 0.05% Sodium Azide
• Purity: Protein A or G purified

Notes

Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.

Alternate Names for ORF73/HHV8 Antibody (LN53) [Janelia Fluor® 525]

• HHV8GK18_gp81
• LANA
• LANA1
• LNA
• ORF73

Background

HHV8 has been found to be associated with three different diseases observed in AIDS patients; kaposi's sarcoma, primary effusion lymphoma (which is a rare type of non-Hodgkin lymphoma affecting the body cavities) and multicentric Castleman's disease. To date there is much evidence to support a direct role for HHV8 in kaposi's sarcoma.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: HHV8GK18_gp81