Immunocytochemistry/ Immunofluorescence: Nitrotyrosine Antibody (39B6) [NB110-96877] - Analysis of Mouse Retinal Injury Model using Nitrotyrosine Antibody (SMC-154). This image is courtesy of Dr. Rajashekhar Gangaraju, ...read more
Immunohistochemistry: Nitrotyrosine Antibody (39B6) [NB110-96877] - Tissue: backskin. Species: Mouse. Fixation: Bouins Fixative and paraffin-embedded. Primary Antibody: Mouse Anti-Nitrotyrosine Monoclonal Antibody at ...read more
Immunohistochemistry-Paraffin: Nitrotyrosine Antibody (39B6) [NB110-96877] - Analysis using Rat Anti-Nitrotyrosine Monoclonal Antibody. Tissue: colon carcinoma. Fixation: Formalin. Primary Antibody: Rat ...read more
Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Alternate Names for Nitrotyrosine Antibody (39B6)
Protein tyrosine nitration results in a post-translational modification that is increasingly receiving attention as an important component of nitric oxide signaling (2). While multiple nonenzymatic mechanisms are known to be capable of producing nitrated tyrosine residues, most tyrosine nitration events involve catalysis by metalloproteins such as myeloperoxidase, eosinophilperoxidase (3), myoglobin, the cytochrome P-450s, superoxide dismutase and prostacyclin synthase. Nitrotyrosine may also serve as a biomarker for the effects of reactive nitrogen oxides, based on tyrosine residues becoming nitrated in proteins at sites of inflammation induced tissue injury (1). The presence of nitro tyrosine-containing proteins therefore has shown high correlation to disease states such as atherosclerosis, Alzheimer's disease, Parkinson's disease and amyotrophic lateral sclerosis (4).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
Publications for Nitrotyrosine Antibody (NB110-96877)(2)
We have publications tested in 2 confirmed species: Human, Mouse.
We have publications tested in 2 applications: ICC/IF, IHC-P.