Macrophage Antibody (EP-3)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications IHC, IHC-P
Clone
EP-3
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

Macrophage Antibody (EP-3) Summary

Immunogen
The antibody reacts with the Macrophage antigen.
Specificity
Monoclonal antibody EP-3 recognizes an antigen associated with the cytoplasm of human macrophages resident in the thymus and other lymphoid tissues. Monoclonal antibody EP-3 can be used to stain cortical thymic macrophages and macro phages in lymphoid and non-lymphoid tissues using routinely fixed and embedded tissues. Thymic tumors may be derived from different cellular components. This monoclonal antibody can be used to identify cortical macrophages and tumors derived from this cell type.
Isotype
IgM
Clonality
Monoclonal
Host
Mouse
Purity
IgM purified
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Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
Monoclonal antibody EP-3 produces a strong cytoplasmic staining pattern of cortical thymic macrophages in formalin fixed, paraffin embedded tissues specimens. It may therefore be used as a marker of this cell type and of tumors derived from the macrophag

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
0.1 mg/ml PBS
Preservative
0.05% Sodium Azide
Purity
IgM purified

Alternate Names for Macrophage Antibody (EP-3)

  • EC 5.3.2.1
  • EC 5.3.3.12
  • GIFmacrophage migration inhibitory factor
  • GLIF
  • Glycosylation-inhibiting factor
  • L-dopachrome isomerase
  • L-dopachrome tautomerase
  • macrophage migration inhibitory factor (glycosylation-inhibiting factor)
  • MMIF
  • Phenylpyruvate tautomerase

Background

Macrophages comprise of many forms of mononuclear phagocytes found in tissues. Mononuclear phagocytes arise from hematopoietic stem cells in the bone marrow. After passing through the monoblast and promonocyte states of the monocyte stage, they enter the blood, where they circulate for about 40 hours. They then enter tissues and increase in size, phagocytic activity, and lysosomal enzyme content becoming macrophages. Among the functions of macrophages are nonspecific phagocytosis and pinocytosis, specific phagocytosis of opsonized microorganisms mediated by Fc receptors and complement receptors, killing of ingested microorganisms, digestion and presentation of antigens to T and B lymphocytes, and secretion of a large number of diverse products, including many enzymes including lysozyme and collagenases, several complement components and coagulation factors, some prostaglandins and leukotrienes, and many regulatory molecules (Interferon, Interleukin 1). Among cells that are now recognized as macrophages are histiocytes, Kupffer cells, osteoclasts, microglial cells, synovial type A cells, interdigitating cells, and Langerhans cells (in normal tissues) and epithelioid cells and Langerhans-type and foreign-body-type multinucleated giant cells (in inflamed tissues).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

Isotype Controls

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