Hepatitis C Virus Core Antigen Antibody (B056M) - BSA Free

• Reactivity: V-Vi
• Applications: ELISA, ICC/IF, WB (-)
• Clone: B056M
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Unconjugated
• Format: BSA Free
• Concentration: 0.1 mg/ml

Hepatitis C Virus Core Antigen Antibody (B056M) - BSA Free Summary

• Description: Novus Biologicals Mouse Hepatitis C Virus Core Antigen Antibody (B056M) - BSA Free (NB110-68197) is a monoclonal antibody validated for use in ELISA and ICC/IF. All Novus Biologicals antibodies are covered by our 100% guarantee.
• Immunogen: Recombinant HCV core antigen, genotype 1a.
• Specificity: Hepatitis C Virus (HCV) Core Antigen. Reactive with genotypes 1a and 2. (B056M)
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Gene: POLY
• Purity: Protein A purified

Applications/Dilutions

• Dilutions:
  • ELISA 1:100-1:2000
  • Immunocytochemistry/ Immunofluorescence 1:10-1:500
• Application Notes: ELISA and IFA. For ELISA, use NB110-68197 as the detection antibody and NB110-68196 as the capture antibody. Does not work in Western Blot.

Reactivity Notes

Hepatitis C Virus

Packaging, Storage & Formulations

• Storage: Store at 4°C.
• Buffer: 10mM PBS (pH 7.2), no stabilizing proteins.
• Preservative: 0.1% Sodium Azide
• Concentration: 0.1 mg/ml
• Purity: Protein A purified

Alternate Names for Hepatitis C Virus Core Antigen Antibody (B056M) - BSA Free

• Core protein p19
• HCcAg
• HCV core antigen
• HCV core protein

Background

The hepatitis C virus (HCV) core protein represents the first 191 amino acids of the viral precursor polyprotein and is cotranslationally inserted into the membrane of the endoplasmic reticulum. Hepatitis C virus (HCV) core is a viral structural protein; it also participates in some cellular processes, including transcriptional regulation. However the mechanisms of core-mediated transcriptional regulation remain poorly understood. Hepatitis C virus (HCV) core protein is thought to contribute to HCV pathogenesis through its interaction with various signal transduction pathways. In addition, HCV core antigen is a recently developed marker of hepatitis C infection. The HCV core protein has been previously shown to circulate in the bloodstream of HCV-infected patients and inhibit host immunity through an interaction with gC1qR. Hepatitis C Virus is a positive, single stranded RNA virus in the Flaviviridae family. The genome is approximately 10,000 nucleotides and encodes a single polyprotein of about 3,000 amino acids. The polyprotein is processed by host cell and viral proteases into three major structural proteins and several non structural proteins necessary for viral replication. Hepatitis C virus (HCV) causes most cases of non-A, non-B hepatitis and results in most HCV infected people developing chronic infections, liver cirrhosis and hepatocellular carcinoma. T cell responses, including interferon-gamma production are severely suppressed in chronic HCV patients.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: POLY