Granzyme G Antibody (207639) [Alexa Fluor® 532]

• Applications: WB
• Clone: 207639
• Clonality: Monoclonal
• Host: Rat
• Conjugate: Alexa Fluor 532

Granzyme G Antibody (207639) [Alexa Fluor® 532] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant mouse Granzyme G
  Ile21-Leu248
  Accession # P13366
• Specificity: Detects mouse Granzyme G in direct ELISAs and Western blots. In Western blots, approximately 5% cross‑reactivity with recombinant mouse Granzyme D is observed.
• Isotype: IgG2a
• Clonality: Monoclonal
• Host: Rat
• Purity Statement: Protein A or G purified

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Background

Granzyme G is a member of the Granzyme family of the serine proteases found specifically in the cytotoxic granules of cytotoxic T lymphocytes (CTL) and natural killer (NK) cells (1). Together with Granzymes D, E and F, it is regulated through pregnancy and by IL‑2 and IL‑15 in granulated metrial gland cells (2). A human or rat counterpart of mouse Granzyme G has not been found. Like other Granzymes, mouse Granzyme G is not secreted as a zymogen but stored as a fully processed and activated enzyme in the cytoplasmic granules of CTL (3). It is synthesized as a 248 amino acid (aa) precursor with a 18 aa signal peptide and a 2 aa propeptide (3, 4).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.